Persistent Identifier
|
doi:10.5683/SP3/5REGAI |
Publication Date
|
2024-02-29 |
Title
| Data for "Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction" in PLOS ONE |
Author
| Grant, Caitlin (Department of Clinical Studies. Ontario Veterinary College. University of Guelph.)
Bakovic, Marica (Department of Human Health and Nutritional Sciences. College of Biological Sciences. University of Guelph.) - ORCID: 0000-0001-9081-3539
Tal, Moran (Department of Clinical Studies. Ontario Veterinary College. University of Guelph.)
Godfrey, Hannah (Department of Biomedical Studies. Ontario Veterinary College. University of Guelph.) - ORCID: 0000-0002-2102-6926
Shoveller, Anna Kate (Department of Animal Biosciences. Ontario Agricultural College. University of Guelph.) - ORCID: 0000-0002-2584-4774
Blois, Shauna (Department of Clinical Studies. Ontario Veterinary College. University of Guelph.)
Hesta, Myriam (Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition. Ghent University.)
Verbrugghe, Adronie (Department of Clinical Studies. Ontario Veterinary College. University of Guelph.) - ORCID: 0000-0001-6366-8866 |
Point of Contact
|
Use email button above to contact.
Verbrugghe, Adronie (Department of Clinical Studies. Ontario Veterinary College. University of Guelph.) |
Description
| This dataset provides the underlying data for a study that aimed to investigate the serum metabolomic profile of obese and lean cats as well as obese cats before and after energy restriction for weight loss. Thirty cats, 16 obese (body condition score 8 to 9/9) and 14 lean (body condition score 4 to 5/9), were fed a veterinary weight loss food during a 4-week period of weight maintenance (L-MAINT and O-MAINT). The 16 obese cats were then energy restricted by a 60 % energy intake reduction with the same food for a 10-week period (O-RESTRICT). Fasted serum metabolites were measured using nuclear magnetic resonance and direct flow injection mass spectrometry after the maintenance period for L-MAINT and O-MAINT cats and after the energy restriction period for O-RESTRICT and compared between groups using a two-sided t-test. Obese cats lost 672 g ± 303 g over the 10-week restriction period, representing a weight loss rate of 0.94 ± 0.28 % per week. Glycine, l-alanine, l-histidine, l-glutamine, 2-hydroxybutyrate, isobutryric acid, citric acid, creatine, and methanol were greater in O-RESTRICT compared to O-MAINT. There was a greater concentration of long-chain acylcarnitines in O-RESTRICT compared to both O-MAINT and L-MAINT, and greater total amino acids compared to O-MAINT. Glycerol and 3-hydroxybutyric acid were greater in O-MAINT compared to L-MAINT, as were several lysophosphatidylcholines. Thus, energy restriction resulted in increased dispensable amino acids in feline serum which could indicate increased amino acid oxidation. Evidence for impaired fatty acid oxidation due to greater circulating acylcarnitines under energy restriction was observed. More research is needed to elucidate energy metabolism and substrate utilization, specifically fatty acid oxidation and methyl status, during energy restriction in strict carnivorous cats to optimize weight loss. |
Subject
| Medicine, Health and Life Sciences |
Keyword
| NMR Metabolomics
DIMS Metabolomics |
Related Publication
| Grant, Caitlin; Bakovic, Marica; Tal, Moran; Godfrey, Hannah; Shoveller, Anna Kate; Blois, Shauna; Hesta, Myriam; and Verbrugghe, Adronie. Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction. PLOS ONE. [Accepted]. |
Language
| English |
Producer
| Verbrugghe, Adronie (Department of Clinical Studies. Ontario Veterinary College. University of Guelph.) |
Funding Information
| Natural Sciences and Engineering Research Council of Canada: RGPIN-2014-04518 |
Distributor
| University of Guelph Research Data Repository (University of Guelph) (UGRDR) |
Depositor
| Godfrey, Hannah |
Deposit Date
| 2023-10-16 |
Time Period
| Start Date: 2015 ; End Date: 2016 |
Date of Collection
| Start Date: 2015-05 ; End Date: 2016-12 |
Data Type
| Experimental data |
Related Dataset
| Tal Gavriel, Moran, 2018, "Fastq files", https://doi.org/10.5683/SP/9VAK4K, Borealis, V1 |