Data from: Recombination and hitchhiking of deleterious alleles

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Hartfield, Matthew; Otto, Sarah P., 2011, "Data from: Recombination and hitchhiking of deleterious alleles", https://doi.org/10.5683/SP2/NB2KLF, Borealis, V1
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Abstract
When new advantageous alleles arise and spread within a population, deleterious alleles at neighbouring loci can hitchhike alongside them and spread to fixation in areas of low recombination, introducing a fixed mutation load. We use branching processes and diffusion equations to calculate the probability that a deleterious allele hitchhikes and fixes alongside an advantageous mutant. As expected, the probability of fixation of a deleterious hitchhiker rises with the selective advantage of the sweeping allele and declines with the selective disadvantage of the deleterious hitchhiker. We then use computer simulations of a genome with an infinite number of loci to investigate the increase in load after an advantageous mutant is introduced. We show that the appearance of advantageous alleles on genetic backgrounds loaded with deleterious alleles has two potential effects: it can fix deleterious alleles and also facilitate the persistence of recombinant lineages that happen to occur. The latter is expected to reduce the signals of selection in the surrounding region. We consider these results in light of human genetic data to infer how likely it is that such deleterious hitchhikers have occurred in our recent evolutionary past. (2020-06-24)
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SimulationsZIP file containing the source code (written in C) for the three main simulations used in the paper (two-locus hitchhiking simulation; three-locus simulation with neutral locus; multi-locus simulation). (2020-06-24)
Subject Other
Keyword Diffusion equations, deleterious mutations, Hill-Robertson effects, selective sweep, Genetic Hitchhiking
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ZIP file containing the source code (written in C) for the three main simulations used in the paper (two-locus hitchhiking simulation; three-locus simulation with neutral locus; multi-locus simulation).
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ZIP file containing the source code (written in C) for the three main simulations used in the paper (two-locus hitchhiking simulation; three-locus simulation with neutral locus; multi-locus simulation).
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