Human health is intimately connected with the tens of trillions of bacteria, fungi and viruses that live symbiotically in and on our bodies. Our microbiota is a remarkable consortium of microbes, unique to each person, and is constantly evolving and adapting. Gut microbes produce compounds that are directly absorbed into our blood, both nourishing us and affecting human functions as diverse as digestion, immunity, and neurodegeneration. The gut microbiota is also malleable, making this ecosystem an enticing target for precision medicine. To date, there have been few direct applications of microbiota therapies in the clinic, due to the lack of understanding of the mechanisms connecting these microbial communities to human health. More than 20 million Canadians suffer every year from digestive disorders that implicate the gut microbiota: it is imperative that we translate what is learned in the lab, and apply it to the clinic.

In the Tropini lab, we are investigating how a disrupted physical environment in diseases such as inflammatory bowel disease (IBD) and chronic diarrhea affect the microbiota and host at a multi-scale level. We are a cross-disciplinary group that incorporates techniques from microbiology, bioengineering, biophysics and more to create highly parallel assays and study how bacteria and communities function, with the eventual goal of translating the knowledge we gain to improve human health.

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1 to 3 of 3 Results
Dec 4, 2023 - UBC Research Data Collection
Burckhardt, Juan C.; Chong, Derrick H.Y.; Pett, Nicola; Tropini, Carolina, 2023, "Gut commensal Enterocloster species host inoviruses that are secreted in vitro and in vivo",, Borealis, V1, UNF:6:sqctiUf1n7f46DpaZwMIfQ== [fileUNF]
This repository contains the raw data for this study. The files are divided based on the figure they contributed to. Each figure folder has a README file that tells you what the files inside it mean. To see the code used to analyze and plot the raw data present, please go to the...
Jun 21, 2023 - UBC Research Data Collection
Yavarinasab, Adel; Flibotte ,Stephane; Liu, Sijie; Tropini, Carolina, 2023, "An impedance-based chemiresistor for the real-time detection of gut microbiota-generated short-chain fatty acids",, Borealis, V1, UNF:6:U9tFVb5Wd5kLLxmE2EGaOQ== [fileUNF]
Short-chain fatty acids (SCFAs) are key molecules produced by gut bacteria in the intestine, that are absorbed into the bloodstream and strongly influence human health. SCFA disruption and imbalances have been linked to many diseases; however, they are seldom used diagnostically...
May 25, 2023
Ng, M. Katharine; Pannu, Sagar; Liu, Sijie; Burckhardt, C. Juan; Hughes, Thad; Van Treuren, Will; Nguyen, Jen; Naviq, Kisa; Nguyen, Bachviet; Clayton, A Charlotte; Pepin, M. Deanna; Collins, R. Samuel; Tropini, Carolina, 2023, "Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota",, Borealis, V1
Abstract Changes to gut environmental factors such as pH and osmolality due to disease or drugs correlate with major shifts in microbiome composition; however, we currently cannot predict which species can tolerate such changes or how the community will be affected. Here, we asse...
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